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https://ahro.austin.org.au/austinjspui/handle/1/21787| Title: | Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease. | Austin Authors: | Hadoux, Xavier;Hui, Flora;Lim, Jeremiah K H;Masters, Colin L ;Pébay, Alice;Chevalier, Sophie;Ha, Jason;Loi, Samantha;Fowler, Christopher J;Rowe, Christopher C ;Villemagne, Victor L ;Taylor, Edward N;Fluke, Christopher;Soucy, Jean-Paul;Lesage, Frédéric;Sylvestre, Jean-Philippe;Rosa-Neto, Pedro;Mathotaarachchi, Sulantha;Gauthier, Serge;Nasreddine, Ziad S;Arbour, Jean Daniel;Rhéaume, Marc-André;Beaulieu, Sylvain;Dirani, Mohamed;Nguyen, Christine T O;Bui, Bang V;Williamson, Robert;Crowston, Jonathan G;van Wijngaarden, Peter | Affiliation: | Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, 3800, Victoria, Australia Research Center, Montreal Heart Institute, Montreal, H1T 1C8, QC, Canada Centre for Astrophysics and Supercomputing, Swinburne University of Technology, Melbourne, 3122, Victoria, Australia McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, H3A 2B4, QC, Canada PERFORM Centre, Concordia University, Montreal, H4B 1R6, QC, Canada Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, Douglas Mental Health University Institute, Montreal, H4H 1R3, QC, Canada Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, H4H 1R3, QC, Canada École Polytechnique de Montréal, Institut de génie biomédical, Département de Génie électrique, Montreal, H3C 3A7, QC, Canada Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, 3002, Victoria, Australia Ophthalmology, Department of Surgery, University of Melbourne, Parkville, 3010, Victoria, Australia Murdoch Children's Research Institute and Department of Paediatrics, University of Melbourne, Melbourne, 3052, Victoria, Australia Department of Optometry and Vision Sciences, University of Melbourne, Parkville, 3010, Victoria, Australia Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore OzGrav-Swinburne, Centre for Astrophysics & Supercomputing, Swinburne University of Technology, Melbourne, 3122, Victoria, Australia Advanced Visualisation Laboratory, Digital Research Innovation Capability Platform, Swinburne University of Technology, Melbourne, 3122, Victoria, Australia Austin Health, Heidelberg, Victoria, Australia The Florey Institute, The University of Melbourne, Parkville, 3010, Victoria, Australia Neuropsychiatry Unit, North Western Mental Health, Melbourne Health, Royal Melbourne Hospital, Parkville, 3050, Victoria, Australia University of Melbourne, Department of Psychiatry, Parkville, 3010, Victoria, Australia Optina Diagnostics, Montreal, H4T 1Z2, QC, Canada Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, H4H 1R3, QC, Canada MoCA Clinic and Institute, Greenfield Park, J4V 2J2, QC, Canada Clinique ophtalmologique 2121, Montreal, H3H 1G6, QC, Canada Département de médecine nucléaire, Hôpital Maisonneuve-Rosemont, Montreal, H1T 2M4, QC, Canada |
Issue Date: | 17-Sep-2019 | Date: | 2019-09-17 | Publication information: | Nature Communications 2019; 10(1): 4227 | Abstract: | Studies of rodent models of Alzheimer's disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of brain Aβ levels. As Aβ has a wavelength-dependent effect on light scatter, we investigate the potential for in vivo retinal hyperspectral imaging to serve as a biomarker of brain Aβ. Significant differences in the retinal reflectance spectra are found between individuals with high Aβ burden on brain PET imaging and mild cognitive impairment (n = 15), and age-matched PET-negative controls (n = 20). Retinal imaging scores are correlated with brain Aβ loads. The findings are validated in an independent cohort, using a second hyperspectral camera. A similar spectral difference is found between control and 5xFAD transgenic mice that accumulate Aβ in the brain and retina. These findings indicate that retinal hyperspectral imaging may predict brain Aβ load. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/21787 | DOI: | 10.1038/s41467-019-12242-1 | ORCID: | 0000-0002-4524-3706 0000-0003-2218-9951 0000-0002-4694-9479 0000-0002-7408-9453 0000-0002-4953-4500 0000-0003-0961-2321 0000-0001-9116-1376 0000-0002-3298-3086 0000-0003-3910-2453 |
Journal: | Nature Communications | PubMed URL: | 31530809 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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