Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/21786
Full metadata record
DC FieldValueLanguage
dc.contributor.authorNg Tang Fui, Mark-
dc.contributor.authorHoermann, Rudolf-
dc.contributor.authorWittert, Gary-
dc.contributor.authorGrossmann, Mathis-
dc.date2019-09-17-
dc.date.accessioned2019-09-23T04:43:00Z-
dc.date.available2019-09-23T04:43:00Z-
dc.date.issued2020-07-
dc.identifier.citationAsian Journal of Andrology 2020; 22(4): 354-359en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/21786-
dc.description.abstractThe aim of this study was to determine whether testicular volume is correlated with clinical and biochemical markers of hypothalamic-pituitary-testicular (HPT) axis function. This was a cross-sectional substudy of a larger randomized controlled trial including obese men, body mass index (BMI) ≥30 kg m-2, with a total testosterone level <12 nmol l-1. Testicular volume was measured by orchidometer, testosterone by liquid chromatography/tandem mass spectrometry, and body composition by dual-energy X-ray absorptiometry. Men completed the Aging Males' Symptoms (AMS) score, International Index of Erectile Function-5 (IIEF-5), physical function, and handgrip dynamometer testing. Eighty-nine men participated with a median (interquartile range [IQR]) age of 53.1 (47.6, 59.2) years, BMI of 37.0 (34.6, 40.5) kg m-2, and a total testosterone of 7.0 (6.1, 7.9) nmol l-1. Median testicular volume was 18 (IQR: 10, 20) ml. Testicular volume was negatively correlated with BMI (τ = -0.1952, P = 0.010) and total fat mass (τ = -0.2115, P = 0.005) independent of age and testosterone. When BMI, testosterone, sex hormone-binding globulin (SHBG), and luteinizing hormone (LH) were present in a multivariable model, only BMI (-0.38 ml change in testicular volume per 1 kg m-2BMI; 95% CI: -0.74, -0.02; P = 0.04) and LH (-0.92 ml change in testicular volume per 1 IU l-1 LH; 95% CI: -1.75, -0.095; P = 0.03) remained independent significant predictors of testicular volume. Testicular volume was positively correlated with IIEF-5 (τ = 0.2092, P = 0.021), but not related to handgrip strength, physical function tests, or AMS. In obese men, testicular volume is inversely and independently associated with measures of adiposity, but not with most clinical or biochemical markers of HPT axis action. From a clinical perspective, this suggests that obesity might compromise the reliability of reduced testicular volume as a sign of androgen deficiency in men.en_US
dc.language.isoeng-
dc.subjectgonadal axisen_US
dc.subjecthypothalamicen_US
dc.subjectpituitaryen_US
dc.subjecttesticular volumeen_US
dc.subjecttestosteroneen_US
dc.titleTesticular volume and clinical correlates of hypothalamic-pituitary-testicular function: A cross-sectional study in obese men.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAsian Journal of Andrologyen_US
dc.identifier.affiliationSchool of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australiaen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationEndocrinologyen_US
dc.identifier.doi10.4103/aja.aja_96_19en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-1326-4270en_US
dc.identifier.orcid0000-0001-8261-3457en_US
dc.identifier.pubmedid31535628-
dc.type.austinJournal Article-
local.name.researcherGrossmann, Mathis
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptEndocrinology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

54
checked on Jan 11, 2025

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.