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https://ahro.austin.org.au/austinjspui/handle/1/21467
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DC Field | Value | Language |
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dc.contributor.author | Anderson, Nigel J | - |
dc.contributor.author | Jackson, James E | - |
dc.contributor.author | Wada, Morikatsu | - |
dc.contributor.author | Schneider, Michal | - |
dc.contributor.author | Poulsen, Michael | - |
dc.contributor.author | Rolfo, Maureen | - |
dc.contributor.author | Fahandej, Maziar | - |
dc.contributor.author | Gan, Hui K | - |
dc.contributor.author | Khoo, Vincent | - |
dc.date | 2019-08-06 | - |
dc.date.accessioned | 2019-08-12T05:00:35Z | - |
dc.date.available | 2019-08-12T05:00:35Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.citation | Journal of Medical Radiation Sciences 2019; 66(4): 250-258 | en_US |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/21467 | - |
dc.description.abstract | Precision radiotherapy relies heavily on optimal weight management. Our group previously developed a risk stratification model for patients at risk of prolonged feeding tube (FT) intervention. The study objective was to assess on-treatment weight loss according to stratified risk of prolonged FT use. One hundred and one (n = 101) definitive head and neck radiotherapy patients were included in this study. Patients were stratified into high risk (HRi: T-classification ≥ 3 with level 2 Nodal disease), high-intermediate risk (HIRi: T-classification ≥ 3 without level 2 Nodes) and low-intermediate risk (LIRi: T-classification < 3 with level 2 Nodes) of prolonged FT use. Demographic variables and on-treatment weight loss were evaluated according to risk status. Oropharyngeal carcinoma (OPC) was present in a larger proportion in the LIRi cohort (HRi: 71%, HIRi: 52%, LIRi: 81%, P = 0.008). LIRi patients were more likely to have human papilloma virus (HPV)-associated disease (88%, P = 0.001). Never/minimal smoking (P = 0.003), good performance status (P < 0.001), healthy BMI (P = 0.050) and no pre-existing dysphagia (P < 0.001) were predominant within the LIRi prognostic group. LIRi patients lost significantly more weight in total (HRi = 4.8% vs. LIRi = 8.2%, P = 0.002; HIRi = 5.2% vs. LIRi = 8.2%, P = 0.006) and when using a FT (HRi = 4.6% vs. LIRi = 8.8%, P < 0.001; HIRi = 5.3% vs. LIRi = 8.8%, P = 0.002). Patients identified as low-intermediate risk of prolonged, ≥25% FT use report significantly increased weight loss compared with patients at higher risk of FT use. This cohort is typical of the increasing number of patients presenting with HPV-associated OPC. Results of this study suggest we should closely observe such patients throughout treatment, to ensure optimal weight maintenance, facilitating precision radiotherapy. | en_US |
dc.language.iso | eng | - |
dc.subject | feeding tube | en_US |
dc.subject | head and neck cancer | en_US |
dc.subject | intensity modulated radiotherapy | en_US |
dc.subject | toxicity | en_US |
dc.subject | weight loss | en_US |
dc.title | The changing landscape of head and neck cancer radiotherapy patients: is high-risk, prolonged feeding tube use indicative of on-treatment weight loss? | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Journal of Medical Radiation Sciences | en_US |
dc.identifier.affiliation | Department of Palliative Care, St Vincent's Hospital, Fitzroy, Victoria, Australia | en_US |
dc.identifier.affiliation | School of Cancer Medicine, La Trobe University School of Cancer Medicine, Melbourne, Victoria, Australia | en_US |
dc.identifier.affiliation | Medical Oncology | en_US |
dc.identifier.affiliation | Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia | en_US |
dc.identifier.affiliation | Department of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia | en_US |
dc.identifier.affiliation | Radiation Oncology | en_US |
dc.identifier.affiliation | Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia | en_US |
dc.identifier.affiliation | Radiation Oncology Centres, Gold Coast University Hospital, Gold Coast, Queensland, Australia | en_US |
dc.identifier.affiliation | Department of Clinical Oncology, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Chelsea, London, UK | en_US |
dc.identifier.affiliation | Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, Australia | en_US |
dc.identifier.affiliation | School of Medicine, Griffith University, Gold Coast, Queensland, Australia | en_US |
dc.identifier.affiliation | Department of Medical Imaging and Radiation Sciences, Monash University, Monash, Victoria, Australia | en_US |
dc.identifier.affiliation | Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia | en_US |
dc.identifier.doi | 10.1002/jmrs.349 | en_US |
dc.type.content | Text | en_US |
dc.identifier.orcid | 0000-0002-4826-2339 | en_US |
dc.identifier.pubmedid | 31385650 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Gan, Hui K | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Journal Article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Radiation Oncology | - |
crisitem.author.dept | Olivia Newton-John Cancer Wellness and Research Centre | - |
crisitem.author.dept | Medical Oncology | - |
crisitem.author.dept | Olivia Newton-John Cancer Wellness and Research Centre | - |
Appears in Collections: | Journal articles |
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