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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20979
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dc.contributor.authorMohandas, Namitha-
dc.contributor.authorLoke, Yuk Jing-
dc.contributor.authorHopkins, Stephanie-
dc.contributor.authorMackenzie, Lisa-
dc.contributor.authorBennett, Carmen-
dc.contributor.authorBerkovic, Samuel F-
dc.contributor.authorVadlamudi, Lata-
dc.contributor.authorCraig, Jeffrey M-
dc.date2019-06-05-
dc.date.accessioned2019-06-19T06:29:49Z-
dc.date.available2019-06-19T06:29:49Z-
dc.date.issued2019-06-
dc.identifier.citationEpigenomics 2019; 11(8): 951-968en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20979-
dc.description.abstractAim: Epilepsy is a common neurological disorder characterized by recurrent seizures. We performed epigenetic analyses between and within 15 monozygotic (MZ) twin pairs discordant for focal or generalized epilepsy. Methods: DNA methylation analysis was performed using Illumina Infinium MethylationEPIC arrays, in blood and buccal samples. Results: Differentially methylated regions between epilepsy types associated with PM20D1 and GFPT2 genes in both tissues. Within MZ discordant twin pairs, differentially methylated regions associated with OTX1 and ARID5B genes for generalized epilepsy and TTC39C and DLX5 genes for focal epilepsy. Conclusion: This is the first epigenome-wide association study, utilizing the discordant MZ co-twin model, to deepen our understanding of the neurobiology of epilepsy.en_US
dc.language.isoeng-
dc.subjectDNA methylationen_US
dc.subjectdiscordant monozygotic twinsen_US
dc.subjectepigeneticsen_US
dc.subjectepilepsyen_US
dc.titleEvidence for type-specific DNA methylation patterns in epilepsy: a discordant monozygotic twin approach.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleEpigenomicsen_US
dc.identifier.affiliationEpilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationSchool of Medicine & Public Health, University of Newcastle, Newcastle, New South Wales, Australiaen_US
dc.identifier.affiliationCentre for Molecular & Medical Research, School of Medicine, Deakin University, Geelong, Victoria 3220, Australiaen_US
dc.identifier.affiliationCentre for Clinical Research, Faculty of Medicine, The University of Queensland, Queensland, Australiaen_US
dc.identifier.affiliationRoyal Brisbane & Women's Hospital, Queensland, Australiaen_US
dc.identifier.affiliationEnvironmental & Genetic Epidemiology Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Paediatrics, University of Melbourne, Flemington Road, Parkville, Victoria, Australiaen_US
dc.identifier.doi10.2217/epi-2018-0136en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-4580-841Xen_US
dc.identifier.pubmedid31166810-
dc.type.austinJournal Article-
local.name.researcherBerkovic, Samuel F
item.languageiso639-1en-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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