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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20893
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dc.contributor.authorPorter, Tenielle-
dc.contributor.authorBurnham, Samantha C-
dc.contributor.authorMilicic, Lidija-
dc.contributor.authorSavage, Greg-
dc.contributor.authorMaruff, Paul-
dc.contributor.authorSohrabi, Hamid R-
dc.contributor.authorPeretti, Madeline-
dc.contributor.authorLim, Yen Ying-
dc.contributor.authorWeinborn, Michael-
dc.contributor.authorAmes, David-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorRainey-Smith, Stephanie R-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorSalvado, Olivier-
dc.contributor.authorGroth, David-
dc.contributor.authorVerdile, Giuseppe-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorLaws, Simon M-
dc.date2019-05-02-
dc.date.accessioned2019-06-05T01:28:47Z-
dc.date.available2019-06-05T01:28:47Z-
dc.date.issued2019-06-
dc.identifier.citationIBRO reports 2019; 6: 147-152en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20893-
dc.description.abstractThe non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer's disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant independent or interactional associations between COMT Val158Met and cognitive decline. These findings do not support previous associations between COMT Val158Met and cognitive performance and suggest this variant does not influence Aβ-amyloid or APOE ε4 driven cognitive decline in a well characterised cohort of cognitively normal older adults.en
dc.language.isoeng-
dc.subjectAβ-amyloiden
dc.subjectCOMTen
dc.subjectCatechol-O-methyltransferaseen
dc.subjectCognitive declineen
dc.subjectEpisodic memoryen
dc.titleCOMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults.en
dc.typeJournal Articleen
dc.identifier.journaltitleIBRO reportsen
dc.identifier.affiliationCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australiaen
dc.identifier.affiliationSchool of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley 6102, Western Australia, Australiaen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationNational Ageing Research Institute, Parkville 3052, Victoria, Australiaen
dc.identifier.affiliationAcademic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew 3101, Victoria, Australiaen
dc.identifier.affiliationSchool of Psychology, University of Western Australia, Crawley 6009, Western Australia, Australiaen
dc.identifier.affiliationCogState Ltd., Melbourne 3000, Victoria, Australiaen
dc.identifier.affiliationCollaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australiaen
dc.identifier.affiliationCSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston 4029, Queensland, Australiaen
dc.identifier.affiliationCSIRO Health and Biosecurity, Parkville 3052, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville 3052, Victoria, Australiaen
dc.identifier.affiliationARC Centre of Excellence in Cognition and its Disorders, Department of Psychology, Macquarie University, North Ryde 2113, NSW, Australiaen
dc.identifier.affiliationCooperative Research Centre for Mental Health, Australiaen
dc.identifier.doi10.1016/j.ibror.2019.05.001en
dc.type.contentTexten
dc.identifier.orcid0000-0003-3910-2453en
dc.identifier.pubmedid31080907-
dc.type.austinJournal Article-
local.name.researcherMasters, Colin L
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
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