Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20444
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dc.contributor.authorVlaskamp, Danique R M-
dc.contributor.authorBassett, Anne S-
dc.contributor.authorSullivan, Joseph E-
dc.contributor.authorRobblee, Jennifer-
dc.contributor.authorSadleir, Lynette G-
dc.contributor.authorScheffer, Ingrid E-
dc.contributor.authorAndrade, Danielle M-
dc.date2019-03-03-
dc.date.accessioned2019-03-14T22:35:09Z-
dc.date.available2019-03-14T22:35:09Z-
dc.date.issued2019-03-
dc.identifier.citationEpilepsia 2019; 60(3): 429-440-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20444-
dc.description.abstractTo investigate the occurrence of psychosis and serious behavioral problems in females with protocadherin 19 gene (PCDH19) pathogenic variants. We evaluated whether psychosis and serious behavioral problems had occurred in 60 females (age 2-75 years) with PCDH19 pathogenic variants belonging to 35 families. Patients were identified from epilepsy genetics databases in Australia, New Zealand, the United States, and Canada. Neurologic and psychiatric disorders were diagnosed using standard methods. Eight of 60 females (13%) from 7 families developed a psychotic disorder: schizophrenia (6), schizoaffective disorder (1), or an unspecified psychotic disorder (1). Median age at onset of psychotic symptoms was 21 years (range 11-28 years). In our cohort of 39 females aged 11 years or older, 8 (21%) developed a psychotic disorder. Seven had ongoing seizures at onset of psychosis, with 2 continuing to have seizures when psychosis recurred. Psychotic disorders occurred in the setting of mild (4), moderate (2), or severe (1) intellectual disability, or normal intellect (1). Preexisting behavioral problems occurred in 4 patients, and autism spectrum disorder in 3. Two additional females (3%) had psychotic features with other conditions: an adolescent had recurrent episodes of postictal psychosis, and a 75-year-old woman had major depression with psychotic features. A further 3 adolescents (5%) with moderate to severe intellectual disability had onset of severe behavioral disturbance, or significant worsening. We identify that psychotic disorders, including schizophrenia, are a later-onset manifestation of PCDH19 Girls Clustering Epilepsy. Affected girls and women should be carefully monitored for later-onset psychiatric disorders.-
dc.language.isoeng-
dc.subjectepilepsy-
dc.subjectpsychiatry-
dc.subjectpsychosis-
dc.subjectpsychotic disorders-
dc.subjectseizures-
dc.titleSchizophrenia is a later-onset feature of PCDH19 Girls Clustering Epilepsy.-
dc.typeJournal Article-
dc.identifier.journaltitleEpilepsia-
dc.identifier.affiliationPediatric Epilepsy Center, Benioff Children's Hospital, University of California San Francisco, San Francisco, California-
dc.identifier.affiliationDivision of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada-
dc.identifier.affiliationDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlandsen
dc.identifier.affiliationDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canadaen
dc.identifier.affiliationDalglish Family 22q Clinic for Adults with 22q11.2 Deletion Syndrome, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canadaen
dc.identifier.affiliationDivision of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canadaen
dc.identifier.affiliationEpilepsy Genetics Research Program, Krembil Neuroscience Centre, University of Toronto, Toronto, Ontario, Canadaen
dc.identifier.affiliationDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlandsen
dc.identifier.affiliationEpilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Paediatrics and Child Health, University of Otago, Wellington, New Zealanden
dc.identifier.affiliationThe Florey Institute of Neurosciences and Mental Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Paediatrics, Royal Children's Hospital, The University of Melbourne, Victoria, Australiaen
dc.identifier.affiliationClinical Genetics Research Program, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canadaen
dc.identifier.doi10.1111/epi.14678-
dc.identifier.orcid0000-0002-6820-8268-
dc.identifier.orcid0000-0002-2311-2174-
dc.identifier.pubmedid30828795-
dc.type.austinJournal Article-
local.name.researcherScheffer, Ingrid E
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptEpilepsy Research Centre-
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