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https://ahro.austin.org.au/austinjspui/handle/1/20298| Title: | Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill. | Austin Authors: | Bitker, Laurent;Burrell, Louise M | Affiliation: | Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia |
Issue Date: | Apr-2019 | Date: | 2019-01-28 | Publication information: | Critical care clinics 2019; 35(2): 213-227 | Abstract: | Classic and nonclassic renin-angiotensin systems (RAS) are 2 sides of an ubiquitous endocrine/paracrine cascade regulating blood pressure and homeostasis. Angiotensin II and angiotensin-converting enzyme (ACE) levels are associated with severity of disease in the critically ill, and are central to the physiology and the pathogenesis of circulatory shock. Angiotensin (1-7) and ACE2 act as an endogenous counterregulatory arm to the angiotensin II/ACE axis. The tissue-based RAS has paracrine effects dissociated from those of the circulating RAS. Exogenous angiotensin II or ACE2 may improve the outcome of septic shock and acute respiratory distress syndrome, respectively. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/20298 | DOI: | 10.1016/j.ccc.2018.11.002 | Journal: | Critical care clinics | PubMed URL: | 30784605 | Type: | Journal Article | Subjects: | Acute kidney injury Acute respiratory distress syndrome Angiotensin Angiotensin-converting enzyme Inflammation Renin Sepsis Septic shock |
| Appears in Collections: | Journal articles |
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