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https://ahro.austin.org.au/austinjspui/handle/1/19986| Title: | BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines. | Austin Authors: | Merino, Delphine;Kelly, Gemma L;Lessene, Guillaume;Wei, Andrew H;Roberts, Andrew W;Strasser, Andreas | Affiliation: | Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC 3000, Australia Victorian Comprehensive Cancer Centre, Melbourne, VIC 3000, Australia Department of Haematology, Alfred Hospital and Monash University Melbourne, Melbourne, VIC 3004, Australia The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC 3010, Australia |
Issue Date: | 10-Dec-2018 | Publication information: | Cancer cell 2018; 34(6): 879-891 | Abstract: | Defects in apoptotic cell death can promote cancer and impair responses of malignant cells to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by keeping the cell death effectors, BAX and BAK, in check. The BH3-only proteins initiate apoptosis by neutralizing the pro-survival BCL-2 proteins. Structural analysis and medicinal chemistry led to the development of small-molecule drugs that mimic the function of the BH3-only proteins to kill cancer cells. The BCL-2 inhibitor venetoclax has been approved for treatment of refractory chronic lymphocytic leukemia and this drug and inhibitors of pro-survival MCL-1 and BCL-XL are being tested in diverse malignancies. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/19986 | DOI: | 10.1016/j.ccell.2018.11.004 | Journal: | Cancer cell | PubMed URL: | 30537511 | Type: | Journal Article | Subjects: | BCL-2 BH3-mimetic drugs BH3-only proteins MCL-1 apoptosis cancer |
| Appears in Collections: | Journal articles |
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