Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19507
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRamchand, Sabashini K-
dc.contributor.authorSeeman, Ego-
dc.date2018-09-05-
dc.date.accessioned2018-09-25T23:00:19Z-
dc.date.available2018-09-25T23:00:19Z-
dc.date.issued2018-
dc.identifier.citationCurrent Osteoporosis Reports 2018; 16(5): 561-572en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19507-
dc.description.abstractBone densitometry provides a two-dimensional projected areal apparent bone mineral density that fails to capture the heterogeneity of bone's material composition and macro-, micro-, and nano-structures critical to its material and structural strength. Assessment of the structural basis of bone fragility has focused largely on trabecular bone based on the common occurrence of fragility fractures at sites with substantial amounts of trabecular bone. This review focuses on the contribution of cortical bone to bone fragility throughout life. Accurately differentiating cortical and trabecular bone loss has important implications in quantifying bone fragility as these compartments have differing effects on bone strength. Recent advances in imaging methodology have improved distinction of these two compartments by (i) recognition of a cortico-trabecular transitional zone and (ii) quantifying bone microstructure in a region of interest that is a percentage of bone length rather than a fixed point. Additionally, non-invasive three-dimensional imaging methods allow more accurate quantification of changes in the cortical, trabecular, and cortico-trabecular compartments during growth, aging, disease, and treatment. Over 75% of the skeleton is assembled as cortical bone. Of all fragility fractures, ~ 80% are appendicular and involve regions rich in cortical bone and ~ 70% of all age-related appendicular bone loss is cortical and is mainly due to unbalanced intracortical remodeling which increases cortical porosity. The failure to achieve the optimal peak bone microstructure during growth due to disease and the deterioration in cortical and trabecular bone produced by bone loss compromise bone strength. The loss of strength produced by microstructural deterioration is disproportionate to the bone loss producing this deterioration. The reason for this is that the loss of strength increases as a 7th power function of the rise in cortical porosity and a 3rd power function of the fall in trabecular density (Schaffler and Burr in J Biomech. 21(1):13-6, 1988), hence the need to quantify bone microstructure.en_US
dc.language.isoeng-
dc.subjectBone strengthen_US
dc.subjectCortical porosityen_US
dc.subjectOsteoporosisen_US
dc.subjectRemodelingen_US
dc.titleThe Influence of Cortical Porosity on the Strength of Bone During Growth and Advancing Age.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleCurrent Osteoporosis Reportsen_US
dc.identifier.affiliationAustralian Catholic University, Melbourne, Australiaen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationEndocrinologyen_US
dc.identifier.doi10.1007/s11914-018-0478-0en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-9692-048Xen_US
dc.identifier.pubmedid30187285-
dc.type.austinJournal Article-
dc.type.austinReview-
local.name.researcherRamchand, Sabashini K
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptEndocrinology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

72
checked on Dec 26, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.