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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18763
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dc.contributor.authorDubois, Bruno-
dc.contributor.authorHampel, Harald-
dc.contributor.authorFeldman, Howard H-
dc.contributor.authorScheltens, Philip-
dc.contributor.authorAisen, Paul-
dc.contributor.authorAndrieu, Sandrine-
dc.contributor.authorBakardjian, Hovagim-
dc.contributor.authorBenali, Habib-
dc.contributor.authorBertram, Lars-
dc.contributor.authorBlennow, Kaj-
dc.contributor.authorBroich, Karl-
dc.contributor.authorCavedo, Enrica-
dc.contributor.authorCrutch, Sebastian-
dc.contributor.authorDartigues, Jean-François-
dc.contributor.authorDuyckaerts, Charles-
dc.contributor.authorEpelbaum, Stéphane-
dc.contributor.authorFrisoni, Giovanni B-
dc.contributor.authorGauthier, Serge-
dc.contributor.authorGenthon, Remy-
dc.contributor.authorGouw, Alida A-
dc.contributor.authorHabert, Marie-Odile-
dc.contributor.authorHoltzman, David M-
dc.contributor.authorKivipelto, Miia-
dc.contributor.authorLista, Simone-
dc.contributor.authorMolinuevo, José-Luis-
dc.contributor.authorO'Bryant, Sid E-
dc.contributor.authorRabinovici, Gil D-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorSalloway, Stephen-
dc.contributor.authorSchneider, Lon S-
dc.contributor.authorSperling, Reisa-
dc.contributor.authorTeichmann, Marc-
dc.contributor.authorCarrillo, Maria C-
dc.contributor.authorCummings, Jeffrey-
dc.contributor.authorJack, Cliff R-
dc.date.accessioned2018-08-30T06:55:16Z-
dc.date.available2018-08-30T06:55:16Z-
dc.date.issued2016-03-
dc.identifier.citationAlzheimer's & dementia : the journal of the Alzheimer's Association 2016; 12(3): 292-323-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18763-
dc.description.abstractDuring the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this "silent" stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations.-
dc.language.isoeng-
dc.subjectAlzheimer's disease-
dc.subjectAmyloid PET-
dc.subjectAsymptomatic-
dc.subjectBiomarkers-
dc.subjectBlood biomarkers-
dc.subjectCSF biomarkers-
dc.subjectDiagnostic criteria-
dc.subjectGenetics-
dc.subjectMRI-
dc.subjectPathophysiology-
dc.subjectPreclinical-
dc.subjectTau PET-
dc.titlePreclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.-
dc.typeJournal Article-
dc.identifier.journaltitleAlzheimer's & dementia : the journal of the Alzheimer's Association-
dc.identifier.affiliationInstitute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France-
dc.identifier.affiliationUniversity Hospitals and University of Geneva, Geneva, Switzerlanden
dc.identifier.affiliationIRCCS Fatebenefratelli, Brescia, Italyen
dc.identifier.affiliationUniversity of British Columbia, Canada-
dc.identifier.affiliationDepartment of Neurology and Alzheimer Center, VU University Medical Center and Neuroscience Campus, Amsterdam, The Netherlands-
dc.identifier.affiliationUniversity of Southern California San Diego, CA, USA-
dc.identifier.affiliationUMR1027, INSERM, Université Toulouse III, Toulouse University Hospital, France-
dc.identifier.affiliationIHU-A-ICM-Institut des Neurosciences translationnelles de Paris, Paris, France-
dc.identifier.affiliationINSERM U1146-CNRS UMR 7371-UPMC UM CR2, Site Pitié-Salpêtrière, Paris, France-
dc.identifier.affiliationLübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany-
dc.identifier.affiliationSchool of Public Health, Faculty of Medicine, Imperial College London, London, UK-
dc.identifier.affiliationClinical Neurochemistry Lab, Department of Neuroscience and Physiology, University of Gothenburg, Mölndal Hospital, Sahlgrenska University Hospital, Mölndal, Sweden-
dc.identifier.affiliationFederal Institute for Drugs and Medical Devices, Bonn, Germany-
dc.identifier.affiliationDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK-
dc.identifier.affiliationINSERM U 1219, Université de Bordeaux, France-
dc.identifier.affiliationUniversity Pierre et Marie Curie, Assistance Publique des Hôpitaux de Paris, Alzheimer-Prion Team Institut du Cerveau et de la Moelle (ICM), Paris, France-
dc.identifier.affiliationMcGill Center for Studies in Aging, Douglas Mental Health Research Institute, Montreal, Canada-
dc.identifier.affiliationFondation pour la Recherche sur Alzheimer, Hôpital Pitié-Salpêtrière, Paris, France-
dc.identifier.affiliationDepartment of Clinical Neurophysiology/MEG Center, VU University Medical Center, Amsterdam-
dc.identifier.affiliationSorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France-
dc.identifier.affiliationAP-HP, Hôpital Pitié-Salpêtrière, Département de Médecine Nucléaire, Paris, France-
dc.identifier.affiliationDepartment of Neurology, Washington University, Hope Center for Neurological Disorders, St. Louis, MO, USA-
dc.identifier.affiliationDepartment of Neurology, Washington University, Knight Alzheimer's Disease Research Center, St. Louis, MO, USA-
dc.identifier.affiliationCenter for Alzheimer Research, Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden-
dc.identifier.affiliationInstitute of Clinical Medicine/ Neurology, University of Eastern Finland, Kuopio, Finland-
dc.identifier.affiliationAXA Research Fund & UPMC Chair, Paris, France-
dc.identifier.affiliationAlzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain-
dc.identifier.affiliationBarcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain-
dc.identifier.affiliationCenter for Alzheimer's & Neurodegenerative Disease Research, University of North Texas Health Science Center, TX, USA-
dc.identifier.affiliationMemory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA-
dc.identifier.affiliationDepartment of Molecular Imaging, Austin Health, University of Melbourne, Australia-
dc.identifier.affiliationMemory and Aging Program, Butler Hospital, Alpert Medical School of Brown University, USA-
dc.identifier.affiliationDepartment of Neurology, Alpert Medical School of Brown University, USA-
dc.identifier.affiliationDepartment of Psychiatry, Alpert Medical School of Brown University, USA-
dc.identifier.affiliationKeck School of Medicine of the University of Southern California, Los Angeles, CA, USA-
dc.identifier.affiliationHarvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, USA-
dc.identifier.affiliationLaboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy-
dc.identifier.affiliationThe Alzheimer's Association Division of Medical & Scientific Relations, Chicago, USA-
dc.identifier.affiliationCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA-
dc.identifier.affiliationDepartment of Radiology, Mayo Clinic, Rochester MN, USA-
dc.identifier.doi10.1016/j.jalz.2016.02.002-
dc.identifier.orcid0000-0003-3910-2453-
dc.identifier.pubmedid27012484-
dc.type.austinJournal Article-
dc.type.austinResearch Support, Non-U.S. Gov't-
dc.type.austinReview-
local.name.researcherRowe, Christopher C
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
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