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https://ahro.austin.org.au/austinjspui/handle/1/17703| Title: | Subthalamic nucleus deep brain stimulation evokes resonant neural activity. | Austin Authors: | Sinclair, Nicholas C;McDermott, Hugh J;Bulluss, Kristian J ;Fallon, James B;Perera, Thushara;Xu, San San ;Brown, Peter;Thevathasan, Wesley | Affiliation: | Bionics Institute, East Melbourne, Victoria, Australia Department of Medical Bionics, University of Melbourne, East Melbourne, Victoria, Australia Department of Neurosurgery, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia Department of Neurosurgery, Austin Health, Heidelberg, Victoria, Australia Department of Neurology, Austin Health, Heidelberg, Victoria, Australia Medical Research Council Brain Network Dynamics Unit and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom Department of Medicine, University of Melbourne, Parkville, Australia Department of Neurology, Royal Melbourne Hospital, Parkville, Australia |
Issue Date: | 2018 | Date: | 2018-05-04 | Publication information: | Annals of neurology 2018; 83(5): 1027-1031 | Abstract: | Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-specific biomarker is required to optimize therapy. Here, we show that DBS evokes a large-amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson disease), coincides with improved clinical performance, is chronically recordable, and is present under general anesthesia. These features make it a readily utilizable electrophysiological signal that could potentially be used for guiding electrode implantation surgery and tailoring DBS therapy to improve patient outcomes. Ann Neurol 2018. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/17703 | DOI: | 10.1002/ana.25234 | Journal: | Annals of neurology | PubMed URL: | 29727475 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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