Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/17686
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Ukor, Ida F | - |
dc.contributor.author | Hilton, Andrew K | - |
dc.contributor.author | Bailey, Michael J | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.date | 2017-05-30 | - |
dc.date.accessioned | 2018-05-08T23:56:50Z | - |
dc.date.available | 2018-05-08T23:56:50Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.citation | Journal of Critical Care 2017; 41: 254-259 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/17686 | - |
dc.description.abstract | This pilot study aimed to characterise the haemodynamic effect of 1L of IV normal saline (NS) administered as a rapid versus slow infusion on cardiac output (CO), heart rate (HR), systemic blood pressures, and carotid blood flow in six healthy volunteers. Six healthy male volunteers aged 18-65years were randomized to receive 1L NS given over 30min or 120min. On a subsequent study session the alternate fluid regimen was administered. Haemodynamic data was gathered using a non-invasive finger arterial pressure monitor (Nexfin®), echocardiography and carotid duplex sonography. Time to micturition and urine volume was also assessed. Compared to baseline, rapid infusion of 1L of saline over 30min produced a fall in Nexfin®-measured CO by 0.62L/min (p<0.001), whereas there was a marginal but significant increase during infusion of 1L NS over 120min of 0.02L/min (p<0.001). This effect was mirrored by changes in HR and blood pressure (BP) (p<0.001). There were no significant changes in carotid blood flow, time to micturition, or urine volume produced. Slower infusion of 1L NS in healthy male volunteers produced a greater increase in CO, HR and BP than rapid infusion. | - |
dc.language.iso | eng | - |
dc.subject | Cardiac output | - |
dc.subject | Fluid therapy | - |
dc.subject | Haemodynamics | - |
dc.subject | Healthy volunteers | - |
dc.subject | Noninvasive monitoring | - |
dc.subject | Resuscitation | - |
dc.subject | Saline | - |
dc.title | The haemodynamic effects of bolus versus slower infusion of intravenous crystalloid in healthy volunteers. | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | Journal of Critical Care | - |
dc.identifier.affiliation | Intensive Care Unit, Austin Health, Heidelberg, Victoria, Australia | - |
dc.identifier.affiliation | Department of Anaesthesia and Perioperative Medicine, Monash Medical Centre, Clayton, Melbourne, Victoria, Australia | - |
dc.identifier.affiliation | Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Centre, Prahran, Melbourne, Victoria, Australia | - |
dc.identifier.doi | 10.1016/j.jcrc.2017.05.036 | - |
dc.identifier.orcid | 0000-0002-1650-8939 | - |
dc.identifier.pubmedid | 28599199 | - |
dc.type.austin | Clinical Trial | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Bellomo, Rinaldo | |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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