Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17686
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dc.contributor.authorUkor, Ida F-
dc.contributor.authorHilton, Andrew K-
dc.contributor.authorBailey, Michael J-
dc.contributor.authorBellomo, Rinaldo-
dc.date2017-05-30-
dc.date.accessioned2018-05-08T23:56:50Z-
dc.date.available2018-05-08T23:56:50Z-
dc.date.issued2017-10-
dc.identifier.citationJournal of Critical Care 2017; 41: 254-259-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17686-
dc.description.abstractThis pilot study aimed to characterise the haemodynamic effect of 1L of IV normal saline (NS) administered as a rapid versus slow infusion on cardiac output (CO), heart rate (HR), systemic blood pressures, and carotid blood flow in six healthy volunteers. Six healthy male volunteers aged 18-65years were randomized to receive 1L NS given over 30min or 120min. On a subsequent study session the alternate fluid regimen was administered. Haemodynamic data was gathered using a non-invasive finger arterial pressure monitor (Nexfin®), echocardiography and carotid duplex sonography. Time to micturition and urine volume was also assessed. Compared to baseline, rapid infusion of 1L of saline over 30min produced a fall in Nexfin®-measured CO by 0.62L/min (p<0.001), whereas there was a marginal but significant increase during infusion of 1L NS over 120min of 0.02L/min (p<0.001). This effect was mirrored by changes in HR and blood pressure (BP) (p<0.001). There were no significant changes in carotid blood flow, time to micturition, or urine volume produced. Slower infusion of 1L NS in healthy male volunteers produced a greater increase in CO, HR and BP than rapid infusion.-
dc.language.isoeng-
dc.subjectCardiac output-
dc.subjectFluid therapy-
dc.subjectHaemodynamics-
dc.subjectHealthy volunteers-
dc.subjectNoninvasive monitoring-
dc.subjectResuscitation-
dc.subjectSaline-
dc.titleThe haemodynamic effects of bolus versus slower infusion of intravenous crystalloid in healthy volunteers.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of Critical Care-
dc.identifier.affiliationIntensive Care Unit, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartment of Anaesthesia and Perioperative Medicine, Monash Medical Centre, Clayton, Melbourne, Victoria, Australia-
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Centre, Prahran, Melbourne, Victoria, Australia-
dc.identifier.doi10.1016/j.jcrc.2017.05.036-
dc.identifier.orcid0000-0002-1650-8939-
dc.identifier.pubmedid28599199-
dc.type.austinClinical Trial-
dc.type.austinJournal Article-
local.name.researcherBellomo, Rinaldo
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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