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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16913
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dc.contributor.authorClemons, Nicholas J-
dc.contributor.authorLiu, David S-
dc.contributor.authorDuong, Cuong P-
dc.contributor.authorPhillips, Wayne A-
dc.date.accessioned2017-10-25T00:17:45Z-
dc.date.available2017-10-25T00:17:45Z-
dc.date.issued2017-07-05-
dc.identifier.citationMolecular & Cellular Oncology 2017; 4(5): e1344757en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16913-
dc.description.abstractEffective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need. We found that mutant p53 impairs the function of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2, commonly known as NRF2), suppresses solute carrier family 7 member 11 (SLC7A11) expression, and diminishes cellular glutamate/cystine exchange. This decreases glutathione biosynthesis, resulting in redox imbalance. Mutant p53 tumors are thus inherently susceptible to further perturbations of the SLC7A11/glutathione axis.en_US
dc.subjectAPR-246en_US
dc.subjectNFE2L2en_US
dc.subjectNRF2en_US
dc.subjectPRIMA-1meten_US
dc.subjectSLC7A11en_US
dc.subjectglutathione (GSH)en_US
dc.subjectp53en_US
dc.subjectreactive oxygen species (ROS)en_US
dc.subjectsystem xC−en_US
dc.subjectxCTen_US
dc.titleInhibiting system xC− and glutathione biosynthesis – a potential Achilles' heel in mutant-p53 cancersen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleMolecular & Cellular Oncologyen_US
dc.identifier.affiliationDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationSir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Surgery, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Surgery (St Vincent's Hospital), The University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/29057306en_US
dc.identifier.doi10.1080/23723556.2017.1344757en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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