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https://ahro.austin.org.au/austinjspui/handle/1/16806| Title: | Treatment of ALK-rearranged non-small cell lung cancer: A review of the landscape and approach to emerging patterns of treatment resistance in the Australian context | Austin Authors: | Itchins, M;Chia, Puey Ling ;Hayes, SA;Howell, VM;Gill, AJ;Cooper, WA;John, Thomas ;Mitchell, Paul L R ;Millward, M;Clarke, SJ;Solomon, B;Pavlakis, N | Affiliation: | Bill Walsh Translational Research Laboratory, Kolling Institute Medical Institute of Research, Royal North Shore Hospital, St Leonards, New South Wales, Australia Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia Northern Cancer Institute, St Leonards, New South Wales, Australia Medical Oncology Unit, Olivia Newton John Cancer and Wellness Centre, Austin Health, Heidelberg, Victoria, Australia Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia Department of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, New South Wales, Australia Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia School of Medicine, Western Sydney University, Sydney, New South Wales, Australia School of Medicine, University of Western Australia, Perth, Western Australia, Australia Department of Medical Oncology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia Linear Clinical Research, Nedlands, Western Australia, Australia Department of Medical Oncology, Royal North Shore Hospital, St Leonards, New South Wales, Australia Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia |
Issue Date: | Aug-2017 | Publication information: | Asia-Pacific Journal of Clinical Oncology 2017; 13 (Supp 3): 3-13 | Abstract: | Since the identification of anaplastic lymphoma kinase (ALK) gene rearrangements in non-small cell lung cancer (NSCLC) in 2005, the treatment of ALK-rearranged NSCLC (ALK+ NSCLC) has evolved at a rapid pace. This molecularly distinct subset of NSCLC has uniquely important biology, clinicopathologic features and mechanisms of drug resistance which impact on the choice of treatment for a patient with this disease. There are multiple ALK tyrosine kinase inhibitors now available in clinical practice with efficacy data continuing to emerge and guide the optimal treatment algorithm. A detailed search of medical databases and clinical trial registries was conducted to capture all relevant articles on this topic enabling an updated detailed overview of the landscape of management of ALK-rearranged NSCLC. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/16806 | DOI: | 10.1111/ajco.12754 | Journal: | Asia-Pacific Journal of Clinical Oncology | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/28795492 | Type: | Journal Article | Subjects: | ALK Non-small cell lung cancer Resistance Survival Tyrosine kinase inhibitors |
| Appears in Collections: | Journal articles |
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