Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/16130
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Eastwood, Peter R | - |
dc.contributor.author | Barnes, Maree | - |
dc.contributor.author | Walsh, Jennifer H | - |
dc.contributor.author | Maddison, Kathleen J | - |
dc.contributor.author | Hee, Geoffrey | - |
dc.contributor.author | Schwartz, Alan R | - |
dc.contributor.author | Smith, Philip L | - |
dc.contributor.author | Malhotra, Atul | - |
dc.contributor.author | McEvoy, R Douglas | - |
dc.contributor.author | Wheatley, John R | - |
dc.contributor.author | O'Donoghue, Fergal J | - |
dc.contributor.author | Rochford, Peter D | - |
dc.contributor.author | Churchward, Thomas J | - |
dc.contributor.author | Campbell, Matthew C | - |
dc.contributor.author | Palme, Carsten E | - |
dc.contributor.author | Robinson, Sam | - |
dc.contributor.author | Goding, George S | - |
dc.contributor.author | Eckert, Danny J | - |
dc.contributor.author | Jordan, Amy S | - |
dc.contributor.author | Catcheside, Peter G | - |
dc.contributor.author | Tyler, Louise | - |
dc.contributor.author | Antic, Nick A | - |
dc.contributor.author | Worsnop, Christopher J | - |
dc.contributor.author | Kezirian, Eric J | - |
dc.contributor.author | Hillman, David R | - |
dc.date | 2011-11 | - |
dc.date.accessioned | 2016-08-15T23:43:46Z | - |
dc.date.available | 2016-08-15T23:43:46Z | - |
dc.date.issued | 2011-11 | - |
dc.identifier.citation | Sleep 2011; 34(11): 1479-1486 | en_US |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/16130 | - |
dc.description.abstract | BACKGROUND: Reduced upper airway muscle activity during sleep is fundamental to obstructive sleep apnea (OSA) pathogenesis. Hypoglossal nerve stimulation (HGNS) counteracts this problem, with potential to reduce OSA severity. STUDY OBJECTIVES: To examine safety and efficacy of a novel HGNS system (HGNS, Apnex Medical, Inc.) in treating OSA. PARTICIPANTS: Twenty-one patients, 67% male, age (mean ± SD) 53.6 ± 9.2 years, with moderate to severe OSA and unable to tolerate continuous positive airway pressure (CPAP). DESIGN: Each participant underwent surgical implantation of the HGNS system in a prospective single-arm interventional trial. OSA severity was defined by apnea-hypopnea index (AHI) during in-laboratory polysomnography (PSG) at baseline and 3 and 6 months post-implant. Therapy compliance was assessed by nightly hours of use. Symptoms were assessed using the Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ), Calgary Sleep Apnea Quality of Life Index (SAQLI), and the Beck Depression Inventory (BDI). RESULTS: HGNS was used on 89% ± 15% of nights (n = 21). On these nights, it was used for 5.8 ± 1.6 h per night. Nineteen of 21 participants had baseline and 6-month PSGs. There was a significant improvement (all P < 0.05) from baseline to 6 months in: AHI (43.1 ± 17.5 to 19.5 ± 16.7), ESS (12.1 ± 4.7 to 8.1 ± 4.4), FOSQ (14.4 ± 2.0 to 16.7 ± 2.2), SAQLI (3.2 ± 1.0 to 4.9 ± 1.3), and BDI (15.8 ± 9.0 to 9.7 ± 7.6). Two serious device-related adverse events occurred: an infection requiring device removal and a stimulation lead cuff dislodgement requiring replacement. CONCLUSIONS: HGNS demonstrated favorable safety, efficacy, and compliance. Participants experienced a significant decrease in OSA severity and OSA-associated symptoms. CLINICAL TRIAL INFORMATION: NAME: Australian Clinical Study of the Apnex Medical HGNS System to Treat Obstructive Sleep Apnea. REGISTRATION NUMBER: NCT01186926. URL: http://clinicaltrials.gov/ct2/show/NCT01186926. | en_US |
dc.subject | Sleep apnea | en_US |
dc.subject | Genioglossus muscle | en_US |
dc.subject | Hypoglossal nerve stimulation | en_US |
dc.subject | Implantable neurostimulator | en_US |
dc.subject | Lung | en_US |
dc.title | Treating obstructive sleep apnea with hypoglossal nerve stimulation | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Sleep | en_US |
dc.identifier.affiliation | Austin Health, Heidelberg, Victoria, Australia | en_US |
dc.identifier.affiliation | Sir Charles Gairdner Hospital, Perth, Western Australia, Australia | en_US |
dc.identifier.affiliation | University of Western Australia, Perth, Western Australia, Australia | en_US |
dc.identifier.affiliation | Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia | en_US |
dc.identifier.affiliation | University of Melbourne, Parkville, Victoria, Australia | en_US |
dc.identifier.affiliation | Johns Hopkins School of Medicine, Baltimore, MD, USA | en_US |
dc.identifier.affiliation | Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA | en_US |
dc.identifier.affiliation | Repatriation General Hospital, Adelaide, South Australia, Australia | en_US |
dc.identifier.affiliation | Westmead Hospital, Sydney, NSW, Australia | en_US |
dc.identifier.affiliation | Westmead Private Hospital, Sydney, NSW, Australia | en_US |
dc.identifier.affiliation | Flinders University, Adelaide, South Australia, Australia | en_US |
dc.identifier.affiliation | University of Minnesota, Minneapolis, MN, USA | en_US |
dc.identifier.affiliation | Brigham and Women's Hospital, Boston, MA, USA | en_US |
dc.identifier.affiliation | Ludwig Engel Centre for Respiratory Research, Westmead Millennium Institute, Westmead, NSW, Australia | en_US |
dc.identifier.affiliation | Adelaide Institute for Sleep Heath, Adelaide, South Australia, Australia | en_US |
dc.identifier.affiliation | University of California San Francisco, San Francisco, CA, USA | en_US |
dc.identifier.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/22043118 | en_US |
dc.identifier.doi | 10.5665/sleep.1380 | en_US |
dc.type.content | Text | en_US |
dc.identifier.orcid | 0000-0003-1471-9318 | en_US |
dc.type.austin | Journal Article | en_US |
local.name.researcher | Barnes, Maree | |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Respiratory and Sleep Medicine | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Respiratory and Sleep Medicine | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Ear Nose Throat / Head and Neck Surgery | - |
crisitem.author.dept | Respiratory and Sleep Medicine | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Respiratory and Sleep Medicine | - |
Appears in Collections: | Journal articles |
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