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https://ahro.austin.org.au/austinjspui/handle/1/12521| Title: | Relationships between performance on the Cogstate Brief Battery, neurodegeneration, and Aβ accumulation in cognitively normal older adults and adults with MCI. | Austin Authors: | Lim, Yen Ying;Pietrzak, Robert H;Bourgeat, Pierrick;Ames, David;Ellis, Kathryn A;Rembach, Alan;Harrington, Karra;Salvado, Olivier;Martins, Ralph N;Snyder, Peter J;Masters, Colin L ;Rowe, Christopher C ;Villemagne, Victor L ;Maruff, Paul | Affiliation: | The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia Commonwealth Scientific Industrial Research Organization Preventative Health National Research Flagship, Australian e-Health Research Centre-BioMedIA, Brisbane, QLD, Australia National Ageing Research Institute, Parkville, Victoria, Australia The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia Cogstate Ltd., Melbourne, Victoria, Australia Department of Neurology, Warren Alpert School of Medicine, Brown University, Providence, RI, USA Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia Centre of Excellence for Alzheimer's Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, WA, Australia The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia Department of Neurology, Warren Alpert School of Medicine, Brown University, Providence, RI, USA yen_ying_lim@brown.edu. |
Issue Date: | 2-Dec-2014 | Publication information: | Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists 2014; 30(1): 49-58 | Abstract: | We investigated the extent to which decline in memory and working memory in beta-amyloid (Aβ) positive non-demented individuals was related to hippocampal atrophy and Aβ accumulation over 36 months. Cognitively normal older adults (CN) (n = 178) and adults with mild cognitive impairment (MCI) (n = 49) underwent positron emission tomography neuroimaging, magnetic resonance imaging, and cognitive assessments at baseline, 18- and 36-months. Relative to Aβ- CNs, Aβ+ CNs and Aβ+ MCIs showed greater rates of cognitive decline, Aβ accumulation, and hippocampal atrophy. Analysis of interrelationships between these Alzheimer's disease markers in Aβ+ CNs and MCIs indicated that rate of Aβ accumulation was associated with rate of hippocampal atrophy (β = -0.05, p = .037), which was in turn associated independently with rate of decline in memory (β = -0.03, p = .032). This suggests that Aβ accumulation precedes any neurodegeneration or clinical symptoms, and that the relationship between Aβ and cognitive decline is mediated by hippocampal atrophy. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12521 | DOI: | 10.1093/arclin/acu068 | Journal: | Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists | URL: | https://pubmed.ncbi.nlm.nih.gov/25467942 | Type: | Journal Article | Subjects: | Episodic memory Hippocampal volume MCI Neuropsychological assessment Preclinical AD β-amyloid |
| Appears in Collections: | Journal articles |
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