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https://ahro.austin.org.au/austinjspui/handle/1/12339| Title: | Improved synthesis of [(18)F]FLETT via a fully automated vacuum distillation method for [(18)F]2-fluoroethyl azide purification. | Austin Authors: | Ackermann, Uwe ;Plougastel, Lucie;Goh, Yit Wooi;Yeoh, Shinn Dee;Scott, Andrew M | Affiliation: | The University of Melbourne, Parkville, Victoria, Australia Ludwig Institute for Cancer Research, Melbourne Branch, Victoria, Australia Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia Ecole National Supérior de Chimie de Rennes, Rennes, France. |
Issue Date: | 24-Jul-2014 | Publication information: | Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine 2014; 94(): 72-6 | Abstract: | The synthesis of [(18)F]2-fluoroethyl azide and its subsequent click reaction with 5-ethynyl-2'-deoxyuridine (EDU) to form [(18)F]FLETT was performed using an iPhase FlexLab module. The implementation of a vacuum distillation method afforded [(18)F]2-fluoroethyl azide in 87±5.3% radiochemical yield. The use of Cu(CH3CN)4PF6 and TBTA as catalyst enabled us to fully automate the [(18)F]FLETT synthesis without the need for the operator to enter the radiation field. [(18)F]FLETT was produced in higher overall yield (41.3±6.5%) and shorter synthesis time (67min) than with our previously reported manual method (32.5±2.5% in 130min). | Gov't Doc #: | 25113535 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12339 | DOI: | 10.1016/j.apradiso.2014.07.009 | Journal: | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine | URL: | https://pubmed.ncbi.nlm.nih.gov/25113535 | Type: | Journal Article | Subjects: | Automation Click chemistry Fluorine-18 Vacuum distillation |
| Appears in Collections: | Journal articles |
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