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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11803
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dc.contributor.authorLiu, Kevin Hen
dc.contributor.authorHuynh, Nhien
dc.contributor.authorPatel, Oneelen
dc.contributor.authorShulkes, Arthuren
dc.contributor.authorBaldwin, Graham Sen
dc.contributor.authorHe, Hongen
dc.date.accessioned2015-05-16T01:25:53Z
dc.date.available2015-05-16T01:25:53Z
dc.date.issued2013-06-26en
dc.identifier.citationCancer Letters 2013; 340(1): 22-9en
dc.identifier.govdoc23811286en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11803en
dc.description.abstractP21 activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by stimulating Wnt/β-catenin and Ras oncogene, which promote CRC survival via stimulation of hypoxia-inducible factor 1α (HIF-1α). The aim of this study was to assess the mechanism involved in the stimulation by PAK1 of CRC survival. PAK1 promoted CRC cell survival by up-regulation of HIF-1α. PAK1 was over-expressed and hyper-activated in tumors of ApcΔ(14/+) mice, which was correlated with over-expression of HIF-1α and β-catenin. Inhibition of PAK1 decreased tumor growth and the expression of HIF-1α and β-catenin in tumors of ApcΔ(14/+) mice, and suppressed xenograft tumor survival in SCID mice. These findings indicate that PAK1 stimulates CRC survival by up-regulation of HIF-1α.en
dc.language.isoenen
dc.subject.otherCRCen
dc.subject.otherHIF-1αen
dc.subject.otherPAK1en
dc.subject.otherβ-Cateninen
dc.subject.otherAnimalsen
dc.subject.otherCell Hypoxiaen
dc.subject.otherCell Survivalen
dc.subject.otherColorectal Neoplasms.enzymology.pathology.therapyen
dc.subject.otherEnzyme Activationen
dc.subject.otherFemaleen
dc.subject.otherGene Expression Regulation, Neoplasticen
dc.subject.otherGene Knockdown Techniquesen
dc.subject.otherHCT116 Cellsen
dc.subject.otherHT29 Cellsen
dc.subject.otherHumansen
dc.subject.otherHypoxia-Inducible Factor 1, alpha Subunit.genetics.metabolismen
dc.subject.otherMaleen
dc.subject.otherMiceen
dc.subject.otherMice, Inbred C57BLen
dc.subject.otherMice, Knockouten
dc.subject.otherMice, SCIDen
dc.subject.otherRNA, Small Interfering.geneticsen
dc.subject.otherTumor Burdenen
dc.subject.otherUp-Regulationen
dc.subject.otherVascular Endothelial Growth Factor A.secretionen
dc.subject.otherbeta Catenin.metabolismen
dc.subject.otherp21-Activated Kinases.antagonists & inhibitors.physiologyen
dc.titleP21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1α.en
dc.typeJournal Articleen
dc.identifier.journaltitleCancer lettersen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1016/j.canlet.2013.06.024en
dc.description.pages22-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23811286en
dc.type.austinJournal Articleen
local.name.researcherHe, Hong
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptSurgery (University of Melbourne)-
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