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Title: | Relationship between language lateralization and handedness in left-hemispheric partial epilepsy. | Austin Authors: | Sveller, C;Briellmann, Regula S;Saling, Michael M ;Lillywhite, L;Abbott, David F ;Masterton, Richard A J;Jackson, Graeme D | Affiliation: | Brain Research Institute, Neurosciences Bldg., Austin Health, Heidelberg West, Victoria, 3081, Australia | Issue Date: | 28-Nov-2006 | Publication information: | Neurology; 67(10): 1813-7 | Abstract: | To investigate the relationship between language lateralization and handedness in patients with epilepsy and a left-sided seizure focus and in healthy control subjects.We recruited a consecutive series of 74 patients and 70 control subjects. Functional MRI, using a noun-verb generation task, was performed to establish the language laterality index (LI). Handedness was quantified using the Edinburgh Handedness Inventory.Patients showed a shift toward atypical language lateralization (0.43 +/- 0.47; controls 0.57 +/- 034; p < or = 0.05) and left-handedness (55 +/- 57; controls 74 +/- 39; p < or = 0.05). The LI and handedness were correlated in patients (r = 0.54; F = 25.9; p < 0.001) but not in control subjects (r = 0.1; F = 0.64; NS). A combination of left-handedness and atypical LI was more frequent in patients (12%) than control subjects (0%; p < or = 0.05). Crossed hemispheric specialization (e.g., right-handedness associated with atypical LI) was equally frequent in patients (20%) and control subjects (16%; NS).In epilepsy patients with a left-sided seizure focus, language lateralization is correlated to handedness. The increased frequency of left-handedness and associated atypical language lateralization is most likely related to the left-hemispheric seizure focus, influencing hemispheric specialization for both domains. | Gov't Doc #: | 17130414 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/10278 | DOI: | 10.1212/01.wnl.0000244465.74707.42 | Journal: | Neurology | URL: | https://pubmed.ncbi.nlm.nih.gov/17130414 | Type: | Journal Article | Subjects: | Adolescent Adult Brain Mapping Cerebral Cortex.pathology.physiopathology.radionuclide imaging Corpus Callosum.physiology Electroencephalography Epilepsies, Partial.diagnosis.physiopathology Female Functional Laterality.physiology Humans Language Language Tests Magnetic Resonance Imaging Male Middle Aged Neural Pathways.pathology.physiopathology.radionuclide imaging Positron-Emission Tomography Tomography, Emission-Computed, Single-Photon Verbal Behavior.physiology |
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