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Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Di Giantomasso, D | en |
dc.contributor.author | Morimatsu, Hiroshi | en |
dc.contributor.author | Bellomo, Rinaldo | en |
dc.contributor.author | May, Clive N | en |
dc.date.accessioned | 2015-05-15T23:35:45Z | |
dc.date.available | 2015-05-15T23:35:45Z | |
dc.date.issued | 2006-08-01 | en |
dc.identifier.citation | Anaesthesia and Intensive Care; 34(4): 427-33 | en |
dc.identifier.govdoc | 16913336 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/10216 | en |
dc.description.abstract | The effect of low-dose vasopressin (AVP) on vital regional circulations may be clinically relevant but has not been fully described. We sought to determine the effect of low-dose AVP on systemic haemodynamics, coronary, mesenteric and renal circulations in the conscious normal and septic mammal. We studied seven Merino sheep using a prospective randomized cross-over double-blind placebo-controlled animal design. We inserted flow probes around aorta, coronary, mesenteric and renal arteries and, three weeks later, we infused low-dose AVP (0.02 IU/min) or placebo in the normal and septic state induced by intravenous E. coli. In normal sheep, AVP (0.02 IU/min) induced a 17% decrease in mesenteric blood flow (393.0+/-134.9 vs 472.1+/-163.8 ml/min, P<0.05) and a 14% decrease in mesenteric conductance (P<0.05). In septic sheep, AVP decreased heart rate and cardiac output by 28% and 22%, respectively (P<0.05). It also decreased mesenteric blood flow and mesenteric conductance by 23% (flow: 468.5+/-159.7 vs 611.3+/-136.3 ml/min, P<0.05; conductance: 6.3+/-2.7 vs 8.2+/-2.7 ml/min/mmHg; P<0.05). Renal blood flow was unchanged but urine output and creatinine clearance increased (P<0.05). We conclude that low-dose AVP infusion has similar effects in the normal and septic mammalian circulation: bradycardia, decreased cardiac output, decreased mesenteric blood flow and conductance and increased urine output and creatinine clearance. This information is important to clinicians considering its administration in humans. | en |
dc.language.iso | en | en |
dc.subject.other | Animals | en |
dc.subject.other | Catheterization, Peripheral | en |
dc.subject.other | Creatinine.blood | en |
dc.subject.other | Escherichia coli Infections.physiopathology | en |
dc.subject.other | Hemodynamics.drug effects | en |
dc.subject.other | Infusions, Intravenous | en |
dc.subject.other | Ovariectomy | en |
dc.subject.other | Regional Blood Flow.drug effects | en |
dc.subject.other | Renal Circulation.drug effects | en |
dc.subject.other | Sepsis.physiopathology | en |
dc.subject.other | Sheep | en |
dc.subject.other | Splanchnic Circulation.drug effects | en |
dc.subject.other | Urodynamics.drug effects | en |
dc.subject.other | Vasoconstrictor Agents.administration & dosage.pharmacology | en |
dc.subject.other | Vasopressins.administration & dosage.pharmacology | en |
dc.title | Effect of low-dose vasopressin infusion on vital organ blood flow in the conscious normal and septic sheep. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Anaesthesia and Intensive Care | en |
dc.identifier.affiliation | Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia | en |
dc.description.pages | 427-33 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/16913336 | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Bellomo, Rinaldo | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Journal Article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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